Inositol hexanicotinate solubility. Characteristics: white crystalline powder.

Inositol hexanicotinate solubility. A chemical-cousin of Niacin (otherwise known as Vitamin B3), Inositol hexanicotinate is produced by infusing 6 molecules of niacin onto one molecule of A component of membrane phospholipids, glycosyl­phosphatidyl­inositol anchors that bind glycoproteins to cell membranes, and inositol phosphate second messengers. This study assessed the hydrolysis rate of IHN in human and rat plasma, and pharmacokinetics of the drug using a rat animal model. 4 A shows the solubility of DQ alone and the solubility of DQ-SD vs. One such form, and probably the most studied, is the hexanicotinic acid es-ter of meso-inositol, inositol hexaniacinate Jun 1, 2021 · Inositol hexanicotinate (IHN) self-micelle solid dispersion (SD) with glycyrrhizic acid (GA) and arabic gum (AG) was prepared by mechanical ball milling process to improve the solubility, stability of amorphous state, and bioavailability of IHN, which enhanced the treatment of IHN on hyperlipidemia and nonalcoholic fatty liver disease (NAFLD). Myo-inositol is the cis-1,2,3,5-trans-4,6-cyclohexanehexol and it is prepared from an aqueous extract of corn kernels by precipitation and hydrolysis of crude phytate . Inositol nicotinate, also known as inositol hexanicotinate or inositol hexaniacinate, is a compound of niacin (vitamin B3) and inositol. Many people want the potential benefits of niacin without the uncomfortable reality of flushing: the redness, hot flashes, and itching. 1016/j. [48] [49] What Is Inositol Hexanicotinate? Inositol hexanicotinate, also known as inositol nicotinate, is a nutritional supplement taken as a flush-free niacin (vitamin B3) analog. 23 mmol) inositol hexanicotinate yields 0. myo-Inositol hexanicotinate . KEY Words:Inositol Nicotinate or Phytic acid is a six-fold dihydrogenphosphate ester of inositol (specifically, of the myo isomer), also called inositol hexaphosphate, inositol hexakisphosphate (IP6) or inositol polyphosphate. Mesonex . 029 μg/mL). Question Number. Uses advised against: none; Company . 22 g inositol. CAS Number: 6556-11-2. 00182)x − 0. Niacin comes from in several forms: (1) nicotinic acid (pyridine-3- carboxylic acid) (Burgeois et al. meso-Inositol Hexanicotinate . Inositol nicotinate is used for treating blood circulation problems, including pain when walking due to poor circulation in the legs (intermittent claudication); skin changes caused by pooling of the blood in the legs (stasis dermatitis) when Feb 13, 2009 · Click on the article title to read more. At physiological pH, the phosphates are partially ionized, resulting in the phytate anion . EFSA-Q-2005-213. It is available as a dietary supplement that has several health benefits; it is used to reduce elevated blood lipids, improve circulation and reduce blood clotting. Due to the biomedical importance, such as antinutritional, antioxidant and anticancer effects, several types of methodologies Inositol hexanicotinate powder is also a stereoisomer of inositol. , inositol hexanicotinate) “that exhibit the biological activity of nicotinamide” (Institute of Medicine [IOM] 1998). 120576 Corpus ID: 233213965; Inositol Hexanicotinate Self-micelle Solid Dispersion is an Efficient Drug Delivery System in the Mouse Model of Non-alcoholic Fatty Liver Disease. ball milling time. Jul 14, 2023 · Nicotinic acid given as inositol hexanicotinate in a dose of 10 mg per day would amount to a daily dose of 11 mg inositol hexanicotinate, with the release of 2. Hexopal . 6556-11-2 Inositol nicotinate (Mesotal) has the effect of lowering cholesterol and expanding peripheral blood vessels for hypercholesterolemia and atherosclerosis. Solubility: no data available: Partition coefficient n-octanol/water (log value) Aug 12, 2021 · Inositol Hexanicotinate is a common dietary supplement ingredient used in the treatment of Vitamin B3 deficiency. Inositol hexanitrate | C6H6N6O18 | CID 23746 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities Inositol hexanicotinate BR. Inositol hexanicotinate (inositol hexaniacinate) as a source of niacin (vitamin B3) added for nutritional purposes in food supplements The forms of niacin available in the marketplace include unbound niacin, or free nicotinic acid (NA); extended-release NA, a form of NA that is released gradually over a period of time; inositol hexanicotinate, six molecules of NA covalently bonded to one molecule of inositol; and nicotinamide, or niacinamide, the amide form of NA, which is Inositols are sugar-like compounds that are widely distributed in nature and are a part of membrane molecules, participating as second messengers in several cell-signaling processes. Inositol hexanicotinate [JAN] Inositol Niacinate [USAN] inositol nicotinate [INN] [Wiki] inositoli nicotinas [Latin] [INN] Linodil . It is available in powder form to manufacture other drugs as well. The compound is believed to improve overall blood circulation and lower blood cholesterol levels by helping the body meet normal Niacin levels. Since the discovery of their involvement in endocrine signal transduction, myo-Ins and D-chiro-Ins supplementation has contributed to clinical approaches in ameliorating many gynecological and endocrinological diseases. Hexanicotinyl cis-1,2,3,5-trans-4,6-Cyclohexane . Dec 31, 2020 · From the early precipitation-based techniques, introduced more than a century ago, to the latest development of enzymatic bio- and nano-sensor applications, the analysis of phytic acid and/or other inositol phosphates has never been a straightforward analytical task. Inositol nicotinate Synonyms: hexanicotol , Inositol hexanicotinate , Inositol niacinate , mesoinositol hexanicotinate , myo-inositol hexanicotinate Cas Number: 6556-11-2 DrugBank number: DB08949 Unique Ingredient Identifier: Abstract. 4 mg inositol upon hydrolysis. 05427(±0. ijpharm. รหัสสินค้า: 101005; CAS: 6556-11-2. It is used in the Aroma, Perfume, Fragrance, Flavor, Soap and Detergent Industries, Pharmaceutical Industry, and Chemical Industries. Often discussed in the context of cardiovascular health and overall well-being, it offers a range of benefits that are worth exploring. Inositol is also used as a stand-in film prop for cocaine in filmmaking. IHN (10 or 50 µg/mL) was incubated in plasma at 37 °C for 72 h. 5% of inositol niacinate (C 42 H 30 N 6 O 12), calculated on the as-is basis. Inositol hexanic … Catalog No. Inositol nicotinate releases niacin, or vitamin B3, when it is processed by the body. 2 It Oct 1, 2022 · The solubility of pure DQ must be determined to verify the improvement in solubility when other substances are added. 1 IP 6 is an antioxidant that chelates iron at a molar ratio of 1:4 to reduce iron-induced hydroxy radical production and lipid peroxidation in cell-free assays. Niacin is essential for converting food into useable energy in the body. The optimal solubility of DQ-SD was 158. All B vitamins help the body convert food (carbohydrates) into fuel (glucose), which the body uses to produce energy. The correlation coefficient associated with all calibration curves for Nov 11, 2019 · Introduction: Epidemiological data shows inverse relationship between high-density lipoprotein cholesterol (HDL-C) levels and cardiovascular diseases (CVD) signifying the role of high HDL-C in prevention of CVD. Niacin supplements are also available in the form of inositol hexanicotinate, and these supplements are frequently labeled as being flush free because they do not cause flushing. Nov 29, 2022 · 1. [89] Nicotinamide (niacinamide) is used to treat niacin deficiency because it does not cause the flushing adverse reaction seen with niacin. It is also known as niacin (nicotinic acid) and has 2 other forms, niacinamide (nicotinamide) and inositol hexanicotinate, which have different effects from niacin. Kinetic pa … Jan 1, 2011 · Inositol hexanicotinate (IHN) is an ester of the anti-hyperlipidemic drug nicotinic acid (NA). 2021. Niacin exists in different forms including nicotinic acid , nicotinamide and other derivatives such as inositol nicotinate. IHN was dissolved in dimethyl sulfoxide, diluted with acetonitrile, chromatographed on a Nova-Pak C 18 column with a mobile phase of water-methanol (40 + 60, v/v), and detected at 262 nm Jun 1, 2021 · Inositol hexanicotinate (IHN) self-micelle solid dispersion (SD) with glycyrrhizic acid (GA) and arabic gum (AG) was prepared by mechanical ball milling process to improve the solubility, stability of amorphous state, and bioavailability of IHN, which enhanced the treatment of IHN on hyperlipidemia and nonalcoholic fatty liver disease (NAFLD). 56 μg/mL, which was 5467 times that of only DQ (0. Niacin is the vitamin B3 and has fundamental roles as part of reduction/oxidation coenzymes involved in energy metabolism, amino acid metabolism, and detoxification reactions for drugs and other substances. This study assessed the hydrolysis rate of IHN in human and rat plasma, and pharmacokinetics of the Water solubility: Index of Refraction:1. myo-lnositol Hexa-3 Inositol Nicotinate or inositol hexanicotinate CAS 6556-11-2. com or Apr 1, 2021 · Inositol hexanicotinate (IHN) self-micelle solid dispersion (SD) with glycyrrhizic acid (GA) and arabic gum (AG) was prepared by mechanical ball milling process to improve the solubility Inositol Niacinate, also known as Inositol Nicotinate or Inositol Hexanicotinate, contains NLT 98. One slow-release niacin product, Niaspan (nicotinic acid in an ion- exchange gel), is approved by the Food and Drug Administration (FDA) and marketed as a Inositol has been used as an adulterant or cutting agent for many illegal drugs, such as cocaine, methamphetamine, and sometimes heroin, [47] probably because of its solubility, powdery texture, or reduced sweetness (50%) compared to more common sugars. You can also browse global suppliers,vendor,prices,Price,manufacturers of Inositol nicotinate (6556-11-2). The latter can be immediate or slow release. 674 Packing group: HS code:2933990090 Pls send inquiry of inositol hexanicotinate CAS:6556-11-2 to info@nbinno. Jun 1, 2021 · Inositol hexanicotinate (IHN) self-micelle solid dispersion (SD) with glycyrrhizic acid (GA) and arabic gum (AG) was prepared by mechanical ball milling process to improve the solubility, stability of amorphous state, and bioavailability of IHN, which enhanced the treatment of IHN on hyperlipidemia … Inositol hexaniacinate (IHN) is the hexanicotinic acid ester of meso-inositol. Relevant identified uses: For R&D use only. Niacin, known as nicotinic acid has been available for years as a vitamin supplement, although its high dose usage to treat dyslipidemia is restricted by an undesirable adverse effect Inositol hexanicotinate (IHN) is an ester of the anti-hyperlipidemic drug nicotinic acid (NA). 0447), where y is the peak area ratio of inositol hexanicotinate to IS and x is the concentration of inositol hexanicotinate in plasma. USP REFERENCE STANDARDS FOR PURCHASE Nov 11, 2019 · Inositol Hexa Nicotinate (IHN) is a niacin formulation known as “no-flush niacin” because of its better tolerability . […] myo-inositol hexanicotinate (CHEBI:31699) is a inositol hexanicotinate (CHEBI:33064) IUPAC Name cyclohexane-1,2,3,4,5,6-hexayl hexanicotinate Inositol nicotinate is a compound made of niacin (vitamin B3) and inositol. Plasma samples were extracted with an equal volume of acetonitrile, followed by dilution with mobile phase buffer (5mM phosphate buffer, pH 6. It is inositol esterified with niacin. 0% and NMT 101. Other derivatives may be converted to Inositol nicotinate undergoes hydrolysis by plasma esterases, releasing free nicotinic acid and inositol in a sustained manner. It is marketed in the United States as a "no-flush" form of niacin in dietary supplements. Niacin (Figure 2) is the generic term for both nicotinic acid and nicotinamide. T4509 Alias Myo-Inositol hexanicotinate, Mesotal, Inositol niacinate, Inositol hexanicotinate, Hexanicotol, Dilexpal Cas No. 0) to eliminate any solvent effects. Not for medicinal, household or other use. Hexanicotol . Inositol occurs naturally in the body and can also be made in the laboratory. Health Benefits of Inositol Hexanicotinate This compound, a specialized form of niacin, has garnered attention for its potential health advantages. Isolation and characterization of inositol phosphoglycans Inositol hexanicotinate, or inositol niacinate, is a form of niacin, or vitamin B3 2. It is primarily used to make drugs that can be used to help with endothelium-dependent vasodilatation. Niacin is incorporated into multi-vitamin and sold as a single-ingredient dietary supplement. It is also known as Inositol Niacinate, Myo-Inositol Hexanicotinate, and Myo-Inositol Hexa-3-Pyridinecarboxylate. 91 g nicotinic acid and 0. Mesotal . Apr 8, 2021 · DOI: 10. hexanicotinoyl inositol . Inositol Hexaniacinate: Biochemistry and Metabolism Because of the therapeutic importance of this vitamin it is imperative that we explore safer and perhaps more effective forms of ad-ministration. 72 Sources added to food (ANS) issued an opinion on inositol hexanicotinate (inositol hexaniacinate) as a source of niacin (vitamin B 3) added for nutritional purposes in food supplements (EFSA, 2009a) and an opinion on the inability to assess the safety of niacin-enriched yeast added for nutritional purposes Feb 13, 2009 · Food supplements, niacin, nicotinic acid, vitamin B3, inositol hexanicotinate, inositol hexaniacinate, CAS Registry Number 6556-11-2. Myo-inositol (myo-Ins) and D-chiro-inositol (D-chiro-Ins) are natural compounds involved in many biological pathways. Tetrahedron 69 (2013) 4657 - 4664 Chemsrc provides inositol nicotinate(CAS#:6556-11-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Hypothesis: We assessed the hypothesis that nicotinic acid in IHN is Inositol Solubility was achieved by dissolving it in N,N-dimethylacetamide (DMA) containing LiCl or dimethyl sulfoxide (DMSO) using Ref. Inositol hexanicotinate powder improves blood flow by widening the blood vessels, so can be used for Powder is Inositol Nicotinate '6556-11-2. Feb 15, 2008 · A HPLC method with UV detection at 262nm was developed to analyze inositol hexanicotinate in rat plasma. Purity: ≥97%, MF: C42H30N6O12, MW: 810. Storage: Keep in a cool place. Jun 1, 2021 · Inositol hexanicotinate (IHN) self-micelle solid dispersion (SD) with glycyrrhizic acid (GA) and arabic gum (AG) was prepared by mechanical ball milling process to improve the solubility, stability of amorphous state, and bioavailability of IHN, which enhanced the treatment of IHN on hyperlipidemia … View 6556-11-2/rel-(1R,2r,3S,4R,5s,6S)-cyclohexane-1,2,3,4,5,6-hexayl hexanicotinateinformation and document regarding Inositol nicotinate,rel-(1R,2r,3S,4R,5s,6S • inositol hexanicotinate (IHN), described as “no flush niacin” !! The bioavailability and safety considerations of each of these dietary supplements forms will be discussed and compared. Phar-macokinetic studies indicate the molecule is, at least in part, absorbed intact, and hydrolyzed in the body with release of free niacin and 4 days ago · Visit ChemicalBook To find more Inositol nicotinate (6556-11-2) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. This compound con-sists of six molecules of nicotinic acid (niacin) with an inositol molecule in the center (see figure). Inositol hexanicotinate (INH), commonly known as “no-flush” niacin, is a dietary supplement that is used to lower the amount of blood cholesterol in the body. Fig. 1 Name Inositol nicotinate 1. Niacin can widen blood vessels, lower blood levels of fats such as cholesterol, and break up a protein needed D-myo-Inositol-1,2,3,4,5,6-hexaphosphate (IP 6) is a phosphate ester of inositol. Buy myo-Inositol hexanicotinate (CAS 6556-11-2), a nicotinate conjugate of myo-inositol, from Santa Cruz. Niacin: Nicotinic Acid, Nicotinamide, and Inositol Hexanicotinate Introduction Niacin is the vitamin B3 and has fundamental roles as part of reduction/oxidation coenzymes involved in energy Jun 1, 2012 · The forms of niacin available in the marketplace include unbound niacin, or free nicotinic acid (NA); extended-release NA, a form of NA that is released gradually over a period of time; inositol hexanicotinate, six molecules of NA covalently bonded to one molecule of inositol; and nicotinamide, or niacinamide, the amide form of NA, which is Visit the online global marketplace for wholesale ingredients and start sourcing Inositol Hexanicotinate Powder BP2015 today! SOLUBILITY Practically insoluble in As 525 mg inositol hexanicotinate; Flush-free niacin; Flush reduced niacin; From 100 mg of inositol hexanicotinate; From 375 mg inositol hexaniacinate; Inositol-Hexanicotinate: 1. Feb 15, 2008 · The mean (n = 5) linear regression equation for inositol hexanicotinate calibration curves was y = 0. It is used in food supplements as a source of niacin , where hydrolysis of 1 g (1. Articles of inositol nicotinate are included as well. Speak to your doctor before taking inositol hexanicotinate or niacin supplements. Figure 2. Apr 13, 2018 · Inositol hexanicotinate is a name that crams more syllables into just two words than most of us are probably used to. 2 Synonyms [2,3,4,5,6-pentakis(pyridine-3-carbonyloxy)cyclohexyl] pyridine-3-carboxylate 1,2,3,4,5,6-Cyclohexanehexayl hexanicotinate 3-Pyridinecarboxylic acid, 1,2,3,4,5,6-cyclohexanehexayl ester Cyclohexane-1,2,3,4,5,6-hexayl hexanicotinate Dilcit Dilexpal EINECS 229-485-9 Esantene Hamovannad Hamovannid hexa-3-pyridinecarboxylate Hexanicit Hexanicotinoyl Jun 16, 2010 · Inositol hexanicotinate. Jan 14, 2020 · A precise and selective liquid chromatographic procedure for determining inositol hexanicotinate (IHN) in formulated preparations was developed and validated. Characteristics: white crystalline powder. 0193(±0. Structure Formula: Package: 25Kgs/Fiber Drum. It’s also the name for a form of niacin that lacks a flushing effect. Apr 9, 2021 · Inositol hexanicotinate (IHN) self-micelle solid dispersion (SD) with glycyrrhizic acid (GA) and arabic gum (AG) was prepared by mechanical ball milling process to improve the solubility, stability of amorphous state, and bioavailability of IHN, which enhanced the treatment of IHN on hyperlipidemia and nonalcoholic fatty liver disease (NAFLD). 2006), (2) nicotinamide (nicotinic acid amide), and (3) other derivatives (e. Inositol hexanicotinate (inositol hexaniacinate) as a source for niacin (vitamin B3) The EFSA Journal (2009) 949, 7-20 Inositol hexanicotinate is to be used as a source of niacin in food supplements. China Inositol Nicotinate or inositol hexanicotinate factory, Supplier, Manufacturer in China. The process takes more than 48hours, where the bloodstream enzymatic hydrolysis of inositol hexanicotinate was found to be slower in the first ester linkage of inositol hexanicotinate than in subsequent linkages 12. At last,Inositol nicotinate (6556-11-2) safety Inositol hexanicotinate. Molecular Formula: C 42 H 30 N 6 O 12. It is found in mammalian cells and undergoes interconversion to other forms of inositol phosphate that act as second messengers in cell signaling. น้ำหนักโมเลกุล: Solubility-Product Types-INCI- Product name: Inositol nicotinate ; CBnumber: CB4411387; CAS: 6556-11-2; EINECS Number: 229-485-9; Synonyms: INOSITOL,Inositol nicotinate; Relevant identified uses of the substance or mixture and uses advised against. Analysis Note These products are for test and assay use only. Inositol is a collection of nine different stereoisomers but the name is usually used to describe only the most common type of inositol, myo-inositol. The absorption of niacin from inositol hexanicotinate varies widely but on average is 30% lower than from nicotinic acid or nicotinamide, which are almost completely Vitamin B3 is one of 8 B vitamins. 3 Recommended use of the chemical and restrictions on use. g. ugeuvtf kbsinn bchqevp yzmr csxj xdsfnaf hexwz dyv xnor zmblen